2-Pyrrolidone （2P）
- EASTCHEM
- China
- One week
- 5000MT per annum
- ≥99.0
- 616-45-5
Ultra-High Purity 2-Pyrrolidone— ≥99.9% Pharmaceutical-Grade Cyclic Solvent with Exceptional Solubility, High Thermal Stability & Ultra-Low Impurities (<1 ppm Metals)
A high-performance solvent engineered for pharmaceutical, lithium battery, electronic chemical, and fine chemical manufacturing, offering outstanding solubility (δ=12.3), complete water miscibility, and stable high-temperature performance (boiling point 245°C), ensuring reliable process efficiency and consistent batch-to-batch quality for industrial-scale production.
Product introduction
2-Pyrrolidone (2-P, Pyrrolidin-2-one, CAS 616-45-5) is a foundational nitrogen-containing cyclic compound, widely recognized as a high-performance solvent and key intermediate in pharmaceuticals, agrochemicals, electronics, and specialty chemical industries.
Our 2-Pyrrolidone 2-P is produced via continuous rectification purification, delivering ≥99.9% purity, meeting USP/EP/JP Pharmacopeia standards, and tailored for mission-critical processes where consistency and regulatory compliance are non-negotiable.
Key Advantages That Matter to Buyers
✅ Unmatched Solvency & CompatibilityWith a solubility parameter of 12.3, 2-Pyrrolidone 2-P is miscible with nearly all organic solvents (alcohols, ethers, esters, aromatics, chlorinated hydrocarbons) and fully water-miscible. It simplifies formulation work, reduces compatibility risks, and enables flexible processing in both aqueous and non-aqueous systems.
✅ High Thermal & Chemical StabilityIts high boiling point (245°C) minimizes solvent loss during high-temperature synthesis or distillation, boosting reaction efficiency and lowering consumption costs. 2-P also exhibits strong resistance to degradation and corrosion, reducing storage risks and extending shelf life.
✅ Pharma-Grade Purity & Batch Consistency
GC-tested purity ≥99.9% with ultra-low moisture (≤0.05%) and metal impurities (<1 ppm)
Batch-to-batch consistency with RSD <0.5% (verified across 100+ production runs)
Compliant with USP/EP/JP pharmacopeia standards for use in drug manufacturing and biotech processes
✅ Regulatory & Supply Chain Reliability
REACH registered, GHS classified as Category 2 irritant
Backed by ISO 9001, ISO 14001, and ISO 45001 certified production facilities
Transparent carbon footprint reporting available (≤1.2 tons CO₂ per ton of product)
Product specification
| Parameter | Value |
|---|---|
| CAS No. | 616-45-5 |
| EINECS No. | 210-483-1 |
| Molecular Formula | C₄H₇NO |
| Molecular Weight | 85.11 g/mol |
| Appearance | Colorless Transparent Liquid |
| Purity (GC) | ≥99.9% |
| Moisture Content | ≤0.05% |
| Metal Impurities | <1 ppm |
| Boiling Point | 245°C |
| Density | 1.116 g/cm³ |
| Solubility Parameter (δ) | 12.3 |
| Water Miscibility | 100% (All Proportions) |
| Flash Point | 129°C (264°F) |
Product Applications
🔹 Industrial & Pharmaceutical Applications
Pharmaceutical & Life Sciences
Key Intermediate for N-Vinylpyrrolidone (NVP) Production: The foundational building block for PVP (Polyvinylpyrrolidone), a critical excipient in drug formulations, cosmetics, and nutraceuticals.
Co-Solvent for Poorly Soluble Drugs: Improves dissolution rates by 30%+ and enhances bioavailability, as validated in antibody drug formulations (e.g., camrelizumab).
Green Solvent for Vaccine Adjuvants: A safer alternative to traditional solvents in biopharmaceutical manufacturing.
Advanced Manufacturing & Electronics
Lithium-Ion Battery Slurry Dispersant: Boosts CNT dispersion efficiency by 50% and reduces graphene slurry viscosity by 40% vs. NMP, improving electrode coating uniformity (RSD ≤3%).
High-End Coating Leveling Agent: Lowers surface tension to 28 mN/m for smoother, more durable coatings.
IC Cleaning Agent: Compatible with copper and aluminum substrates for precision electronics manufacturing.
Other Key Uses
Extraction agent for aromatic compounds and high-value specialty chemicals
Starting material for organic synthesis (γ-amino acid derivatives, n-methylol compounds)
Solvent for agricultural chemicals, synthetic resins, and printing inks
Real-World Success Stories
Case 1: Antitumor Drug Formulation OptimizationA leading pharma manufacturer used our 2-P as a co-solvent for camrelizumab formulations, increasing drug loading from 8 mg/mL to 15 mg/mL and improving bioavailability by 22%.
Case 2: EV Battery Electrode ProductionIn a new energy battery line, 2-P reduced graphene slurry viscosity by 40% (vs. NMP solvent), delivering electrode coating uniformity with RSD ≤3% and cutting production waste.
Packaging & Storage
Standard Packaging: 200 kg nitrogen-sealed anti-static PE drums; 1000L IBC containers available
Custom Packaging: Tailored solutions for sensitive applications (moisture/oxygen-free packaging on request)
Storage Guidelines: Keep in a cool, dry, well-ventilated warehouse; avoid direct sunlight, heat sources, and open flames. Containers must remain sealed to prevent contamination.
FAQ
Q1: Can you provide a Certificate of Analysis (COA) for each batch?
A: Yes. Every shipment includes a detailed COA with full quality data (purity, moisture, impurities) to support regulatory compliance and production validation.
Q2: Do you offer sample testing for new customers?
A: Absolutely. We provide lab-scale samples so you can verify performance in your formulations before placing bulk orders.
Q3: What is your supply capacity and lead time for large orders?
A: With stable production lines and sufficient inventory, we support orders from small R&D batches to full-scale industrial volumes, ensuring on-time delivery globally.
Q4: Are your products compliant with international standards?
A: Our 2-P meets USP/EP/JP pharmacopeia standards, is REACH registered, and is backed by ISO 9001, ISO 14001, and ISO 45001 certifications. Custom compliance documentation is available upon request.