2-methyltetrahydrofuran
- EASTCHEM
- China
- 15~20 days
- ≥99.0%
- 96-47-9
It is main feedstock for synthesising medicines such as chloroquine phosphate, primaquine phosphate and so on.
Name | 2-Methyltetrahydrofuran |
CAS | 96-47-9 |
Molecular formula | C5H10O |
Molecular weight | 86.13 |
EINECS | 202-507-4 |
Melting point | -136 °C |
Boiling point | 78-80 °C(lit.) |
Density | 0.86 g/mL at 25 °C(lit.) |
Refractive index | n20/D 1.406(lit.) |
Flash point | 10.4 °F |
Storage conditions | Flammables area |
Solubility | 150g/l |
Explosive limit | 1.2-5.7%(V) |
Water solubility | 15 g/100 mL (25 C) |
Freezing point | -136℃ |
Stability | Stable, but highly flammable. Incompatible with oxidizing agents, strong acids, strong bases. May form explosive peroxides in storage, so often supplied with an inhibitor added. |
Production method
2-methylfuran catalytic hydrogenation derived.
For pharmaceutical intermediates
1.Mainly used as solvents for resins, natural rubber, ethyl cellulose and chloroacetic acid-vinyl acetate copolymers, and in the pharmaceutical industry for the synthesis of antibiotics such as primaquine phosphate.
2.It can be used as raw materials for synthetic drugs such as chloroquine phosphate and primaquine phosphate, as well as as as as solvents.
Pharmaceutical Applications of 2-Methyltetrahydrofuran
2-Methyltetrahydrofuran (2-MeTHF) is a useful solvent and reaction medium in pharmaceutical manufacturing. Its good solvency and compatibility with many organic compounds make it suitable for different stages of pharmaceutical intermediate synthesis and process development.
In pharmaceutical processes, 2-MeTHF can be used as a solvent for organic reactions, extraction and separation, especially when manufacturers need an alternative to conventional ether or hydrocarbon solvents. It can also be used in processes involving moisture-sensitive or air-sensitive reagents when appropriate process conditions are maintained.
Pharmaceutical Intermediate Synthesis
One important application of 2-Methyltetrahydrofuran is its use in the synthesis of pharmaceutical intermediates. It can provide a suitable reaction environment for preparing various organic compounds and can be incorporated into multi-step synthesis routes.
2-MeTHF has been used as a solvent in the preparation of intermediates related to antimalarial and other pharmaceutical compounds, including routes associated with primaquine phosphate and chloroquine phosphate. Its role is mainly as a process solvent rather than as an active pharmaceutical ingredient.
Solvent for Pharmaceutical Reactions
During pharmaceutical synthesis, solvent selection can affect reaction efficiency, phase separation and subsequent purification. 2-Methyltetrahydrofuran offers good solvency for a range of organic substances and can be used in reactions involving organometallic reagents, reductions, extractions and other synthetic steps, depending on the process.
For manufacturers developing or optimizing a pharmaceutical process, 2-MeTHF can therefore be considered when a suitable organic solvent is needed for both reaction and downstream processing.
Extraction and Separation
Beyond chemical synthesis, 2-MeTHF can be used in liquid-liquid extraction and product isolation. Its organic-phase behavior allows it to participate in the separation of target compounds from aqueous reaction mixtures.
This can be useful in pharmaceutical intermediate production, where extraction is often an important step between synthesis, washing and purification.
Why 2-MeTHF Is Useful in Pharmaceutical Manufacturing
For pharmaceutical applications, the value of 2-MeTHF is not limited to its ability to dissolve compounds. It can also support several practical process steps, including:
Pharmaceutical intermediate synthesis
Organic reaction solvent
Extraction and phase separation
Reaction work-up
Product isolation
Process development and solvent replacement studies
The specific suitability of 2-MeTHF depends on the reaction system, raw materials, equipment and purification route. For commercial production, customers should select the appropriate grade and specification according to their process requirements.
Why Choose EastChem for ?
EastChem supplies 2-Methyltetrahydrofuran with stable specifications and complete product documents. We can arrange suitable packaging, quantities and shipping according to your requirements, making the purchasing process straightforward.
FAQ
What is 2-Methyltetrahydrofuran mainly used for?
It is mainly used as an organic solvent in pharmaceutical synthesis, chemical reactions, extraction and other industrial processes.
Can 2-MeTHF be used for pharmaceutical intermediate production?
Yes. It can be used as a process solvent in the synthesis of pharmaceutical intermediates, including certain routes related to primaquine phosphate and chloroquine phosphate.
What information is needed for a quotation?
Please send the required quantity, specification, packaging and destination. We can then check the suitable supply and shipping options.